Case Study #1

Diabetic Macular Edema (DME)

Patient Profile
63 Female
(postmenopausal)
Diabetic Macular Edema (DME) OD
  • Type 2 Diabetes
  • Hypertension
  • Hypercholesterolemia
  • Moderate non-proliferative diabetic retinopathy
  • This patient is from the FAME study

Treatment History

  • October 18,2006

    Patient received singular ocular steroid injection.

  • November 9,2006

    Patient received focal laser.

Case Study #1 Results with ILUVIEN Treatment1
(ILUVIEN injection date 05/02/2007)

70% Complete
Visit Date Visual Acuity Tx Decision
05/02/2007

20/100

Letters:53 Lines:10

ILUVIEN Injected
05/09/2007

20/80

Letters:58 Lines:11

No Treatment Needed
05/23/2007

20/64

Letters:60 Lines:12

No Treatment Needed
06/07/2007

20/80

Letters:58 Lines:11

No Treatment Needed
08/01/2007

20/100

Letters:50 Lines:10

Focal Laser
10/24/2007

20/80

Letters:57 Lines:11

No Treatment Needed
01/31/2008

20/100

Letters:53 Lines:10

Cateract extracted 3/5/2008
04/24/2008

20/40

Letters:72 Lines:14

No Treatment Needed
05/22/2008

20/32

Letters:74 Lines:15

No Treatment Needed
07/23/2008

20/40

Letters:73 Lines:15

No Treatment Needed
10/22/2008

20/32

Letters:74 Lines:15

No Treatment Needed
01/15/2009

20/32

Letters:77 Lines:15

No Treatment Needed
04/23/2009

20/26

Letters:81 Lines:16

Focal Laser

Results Notes

  • Time to cataract surgery was ~10 months from initiation of ILUVIEN treatment
  • At month 24, there was a visual acuity gain of 28 letters (~5 lines) from baseline
  • Visual acuity of ≥20/40 was seen at all visits following cataract surgery

    Optical coherence tomography †Center point foveal thickness

Intraocular Pressure with ILUVIEN Treatment

  • There were no surgical procedures required to alleviate IOP
 

References:

1. Data on File. Alimera Sciences, Inc.